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The Genius Beethoven died from lead poisoning .His concentrations were 100x any normal level. This was also the cause of his life long painful illness, severe dramatic mood swings, extremely erratic behavior. This was proven by a hair analysis

Poisoned President
Andrew Jackson [1767-1845] experienced severe mercury & lead poisoning. He suffered from severe chronic head aches, colic, diarrhea, hand tremor, violent mood swings, pallor, irritability, paranoia and chronic renal failure. Jury still out if mercury /lead were actual cause of death. Evidence was a hair analysis